TORIPALIMAB IN AN ADVANCED NON-SMALL CELL LUNG CANCER PATIENT WITH POOR GENERAL CONDITION AFTER MULTILINE TREATMENT: A CASE REPORT

Toripalimab in an advanced non-small cell lung cancer patient with poor general condition after multiline treatment: a case report

Several clinical trials have proven that immunotherapy can improve survival and benefit non-small cell lung cancer (NSCLC) patients.In patients who progress after chemotherapy, immune checkpoint inhibitor (ICI) monotherapy can prolong overall survival compared with patients receiving single-agent chemotherapy.A 61-year-old man diagnosed with advanc

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Integrated single-cell and bulk RNA sequencing reveals CREM is involved in the pathogenesis of ulcerative colitis

Background: Ulcerative colitis (UC) is an inflammatory bowel disease characterized by persistent colonic inflammation.Here, we performed a systematic analysis to gain better insights into UC pathogenesis.Methods: We analyzed two UC-related datasets extracted from the gene expression omnibus database using several bioinformatics tools.The primary ce

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Focal cortical dysplasia as a cause of epilepsy: The current evidence of associated genes and future therapeutic treatments

Focal cortical dysplasias (FCDs) are the most common cause of treatment-resistant epilepsy affecting the pediatric population.Most individuals with FCD have seizure onset within the first five years of life and the majority will develop epilepsy by Height Adjuster the age of sixteen.Many cases of FCD are postulated to be the result of abnormal brai

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